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what we do

Our work is to understand fundamental cell processes conserved through the kingdom of all self sustaining life forms. In particular we focus on the cell cycle machinery as a crucial target of the many signaling pathways that coordinate growth and development.

Our approach blends biochemical, small molecule, genetic approaches,high content microscopy, mass spectrometry and computational methods to decipher and predict how those processes work and how they are regulated by extracellular signals. Our people span the disciplines of synthetic biology, systems biology, chemical biology and microbiology.

Our vision. is to significantly contribute to drug design technologies that efficiently regulate cell processes and stay ahead of emerging diseases and drug resistancies. Understand the full complexity of the cell cycle and its components and regulatory mechanisms.

software and tools


The BioGRID is a resource of curated and high throughput physical and genetic interaction data. It contains interactions for
S. cerevisiae, S. pombe, A. thaliana, H. sapiens, M. musculus, D. melanogaster & C. elegans, .
It is updated every month and is freely available to search and download.
access the database >>


Osprey is a tool for visualisation and manipulation of molecular interaction networks connected with BioGRID.
download >>

The chemical genomic portrait of yeast is published in Science.

Mike Tyers, director of the Scottish Universities Life Sciences Alliance, Edinburgh, Scotland

The latest update of BioGRID is published in Nucleic Acids Research.

Chemical genetics reveals a complex functional ground state of neural stem cells.

Drs. Mike Tyers and Jeff Wrana named Howard Hughes Research Scholars

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