After collecting the genome of a vast majority of organism the remaining challenge is to understand the concerted action of its transcriptional regulators and epigenetic mechanisms. A vast variety of approaches refitted from mathematical, engineering and computerscience application has been applied to elicit the codes orchestration and secret dirigents of cellular mechnisms. Many of them were prospering to be the key to natures sanity in the booming years of the first high throughput datasets.
To evaluate those algorithm we build a testing platform that generates artificial expression data based on underlying network topologies and differential equations. Access to IoRN >>
Wildenhain et al. Reconstructing gene regulatory networks: from random to scale-free connectivity.
van Steensel et al. Mapping of genetic and epigenetic regulatory networks using microarrays.
Batada et al. Stratus not altocumulus: a new view of the yeast protein interaction network.